EC Number   |
Expression |
Reference |
|---|
   3.4.24.71 | down |
nitric oxide decreases the expression of ECE-1 through a cGMP/PKG-dependent regulatory mechanism at the post-transcriptional level via the 3'-UTR of the ECE-1 gene |
718716 |
| 3.4.24.71 | down |
siRNA-mediated knockdown of ECE-1 results in a significant reduction in FAK phosphorylation |
719207 |
| 3.4.24.71 | down |
the enzyme expression is markedly inhibited by its 3'-untranslated region |
735130 |
| 3.4.24.71 | up |
alternative polyadenylation results in the production of enzyme transcripts with truncated 3'-untranslated regions which promote elevated protein expression |
735130 |
| 3.4.24.71 | up |
cyclosporine A intensifies renal enzyme expression. The enzyme is upregulated by hypoxia via hypoxia-inducible factor |
752412 |
| 3.4.24.71 | up |
enzyme expression is significantly increased in the placenta and its implantation site of pregnant hyperinsulinemic rats. In the kidney and heart, protein expression is increased by 230 and 220%, respectively, while its level in the liver is similar in normal and hyperinsulinemic rats |
733056 |
| 3.4.24.71 | up |
the mRNA expression of isoforms ECE-1a and -b is upregulated in biliary cirrhosis and in CCl4-injured livers, whereas isoform ECE-1c mRNA remains unchanged. Enzyme activity is increased after bile duct occlusion and peaks at 12 h after acute CCl4-intoxication |
752491 |
| 3.4.24.71 | up |
transient ECE-1 overexpression in PNT1-a cells increases FAK phosphorylation |
719207 |
