EC Number   |
Expression |
Reference |
|---|
   2.8.2.30 | down |
3-OST3A is epigenetically repressed in all breast cancer cell lines of a panel representative of distinct molecular subgroups, except in human epidermal growth factor receptor 2-positive (HER2+) sloan-kettering breast cancer (SKBR3) cells. Epigenetic mechanisms involve both DNA methylation and histone modifications, producing different repressive chromatin environments depending on the cell molecular signature |
762063 |
| 2.8.2.30 | down |
3-OST3A is epigenetically repressed in breast cancer cell lines (except SKBR-3 cells) |
739207 |
| 2.8.2.30 | down |
HS 2-O sulfotransferase 1 (HS2ST1, EC 2.8.2.) is downregulated at both mRNA and protein levels during granulocytic differentiation of SKM-1 leukemia cells and also HS (glucosamine) 3-O sulfotransferase 3A (HS3ST3A) in epithelial-mesenchymal transition (EMT) of A-549 lung cancer cells, meanwhile, cell-surface HS recognized by anti-HS antibody is also changed in both cancer cell lines. HS3ST3A is negatively correlated with the in vitro cell metastasis capability of A549 cells confirmed by RNA interference technology, wound-healing assay and in vitro Matrigel invasion assay |
761220 |
| 2.8.2.30 | down |
mRNA expression of isoform HS3ST3A1 is decreased by 27% in placental tissue obtained from preeclamptic compared to normotensive women |
739264 |
| 2.8.2.30 | down |
the enzyme is down-regulated 10fold in the hepatocytes of chronic hepatitis B virus infection model |
726527 |
| 2.8.2.30 | down |
when HS3ST3B1 is knocked down by specific small interfering RNA in the mesenchymal phenotype, mesenchymal phenotype is transformed to epithelial phenotype. HS3ST3B1 can be targeted by miR-218 in non-small cell lung cancer cells (NSCLC) |
761577 |
| 2.8.2.30 | down |
ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. CRISPR-mediated targeting and siRNA knockdown of ZNF263 in mammalian cell lines and human primary cells leads to dramatically increased expression levels of HS3ST1. LC-MS analysis of lyase-resistant 3-O-sulfated tetrasaccharides derived from ZNF263-/- cells |
762294 |
| 2.8.2.30 | more |
expression of the genes encoding HS-modifying enzymes is frequently dysregulated in cancer and other diseases |
761164 |
| 2.8.2.30 | up |
exposure of chondrosarcoma cells to 5-aza-2'-deoxycytidine up-regulates expression of 3-OST3A mRNA |
703620 |
| 2.8.2.30 | up |
following treatment with 5-aza-2'-deoxycytidine at 24 h and both 5-aza-2'-deoxycytidine in combination with trichostatin-A at 48 h, isoform 3-OST-3B1 gene expression is activated in the pancreatic cancer cell line PANC-1 |
724692 |
