EC Number   |
Expression |
Reference |
|---|
    2.7.1.22 | down |
nicotinamide riboside kinase 2 (NRK2) expression is decreased in wild-type muscle |
-, 760203 |
| 2.7.1.22 | up |
depression of NAD+ availability leads to activation of NRK2. In cardiomyocytes, the NRK2 gene is activated by energy stress and NAD+ depletion through AMP-activated protein kinase and peroxisome proliferator-activated receptor alpha dependant mechanisms |
-, 760203 |
| 2.7.1.22 | up |
following injury to dorsal root ganglion neurons, Nmrk2 is the most upregulated NAD+ biosynthetic gene (by over 20fold). Mice with a loss of hexose-6-phosphate dehydrogenase (H6PDH) function, an ER-based enzyme required for local NADPH generation, manifest with severe muscle myopathy and on transcriptional analysis Nmrk2 expression is the most dysregulated gene (upregulated by over 60fold mRNA level). Nmrk2 mRNA expression is substantially induced (over 80fold) in models of lethal cardiomyopathy |
761705 |
| 2.7.1.22 | up |
Nmrk2 mRNA expression is substantially induced (over 80fold) in models of lethal cardiomyopathy |
761705 |
| 2.7.1.22 | up |
NRK-2 expression dramatically increases in ischemic heart |
-, 758846 |
