EC Number   |
Expression |
Reference |
|---|
   2.6.1.52 | down |
GOT1 expression level is reduced in TAZ/YAP siRNA knockout cells. The inhibition of transamination preferentially suppresses those breast cancer cells that express high levels of TAZ/YAP (e.g. MDA-MB-231 and HCC38 cells ), not TAZ/YAP-low-level expressing cell lines (e.g. BT474 and HMT-3522 S1) |
759123 |
| 2.6.1.52 | down |
mRNA expression levels of the PSAT gene are down-regulated under both low- and high-temperature stress |
737659 |
| 2.6.1.52 | more |
no significant changes in the mRNA expression levels of phosphoglycerate dehydrogenase and phosphoserine aminotransferase occur after the incubation of L-serine with Acanthamoeba castellanii |
739236 |
| 2.6.1.52 | up |
PSAT1 is overexpressed in colorectal tumor samples |
705666 |
| 2.6.1.52 | up |
transcriptional regulators TAZ and YAP (TAZ/YAP) promote glutamine dependence in breast cancer cells and activate the expression of glutamine-utilizing transaminases to support cell growth. TAZ/YAP induce glutamic-oxaloacetic transaminase (GOT1) and phosphoserine aminotransferase (PSAT1) expression. TAZ and YAP are required for glutamine-utilizing transaminase expression in breast cancer cells |
759123 |
