EC Number   |
Expression |
Reference |
|---|
   2.4.2.12 | down |
enzyme expression is decreased by insulin, PI3K and AKT inhibitors, quercetin |
735872 |
| 2.4.2.12 | down |
expression of Nampt in the heart is significantly decreased by ischemia, ischemia/reperfusion and pressure overload. Downregulation of Nampt increases caspase 3 cleavage, cytochrome c release, and TUNEL-positive cells, which are inhibited in the presence of Bcl-xL, but do not increase hairpin 2positive cells, suggesting that endogenous Nampt negatively regulates apoptosis but not necrosis. Downregulation of Nampt also impairs autophagic flux |
703243 |
| 2.4.2.12 | down |
high fat diet reduces enzyme expression in the atrial tissues |
759372 |
| 2.4.2.12 | down |
miR410 directly inhibits enzyme expression |
760186 |
| 2.4.2.12 | down |
the expression level of the enzyme decreases as a result of Abeta1-40x1einduced neuronal toxicity |
759783 |
| 2.4.2.12 | more |
upon aging: enzyme level increases in serum but decreases in brain, decreases in cortex and hippocampus but remains unchanged in cerebellum and striatum in brain, and increases in microglia but likely decreases in neuron |
723588 |
| 2.4.2.12 | up |
administration of 0.1 mM salidroside alleviates Abetax1einduced cell damage and increases the expression level of the enzyme |
759783 |
| 2.4.2.12 | up |
enzyme expression is increased by Ox-LDL, CTRP3, glucose, rosiglitazone, adipocyte differentiation, ATP, LPS, CoCl2, ischaemia, OGD, anti-CD38 and differentiation in CCL, oxidative stress (H2O2), hypoxia, TNF-alpha, interleukin-1beta, starvation, and C-peptide |
735872 |
| 2.4.2.12 | up |
increased during macrophage differentiation |
722182 |
| 2.4.2.12 | up |
the enzyme is often overexpressed in tumor tissues, including in breast, gastric, pancreatic, colorectal, ovarian, prostate, thyroid and endometrial carcinomas as well as in brain tumors, sarcoma, melanoma and hematological malignancies |
760200 |
