EC Number   |
Expression |
Reference |
|---|
    2.4.2.10 | down |
low expression in normal prostate gland tissue |
706025 |
| 2.4.2.10 | down |
mRNA expression of OPRT is markedly decreased to 12.4% and activity to 46.9% in the 5-fluorouracil resistant MKN-45/F2R cell line compared to the MKN-45 parent cell line. OPRT gene expression is markedly decreased to 14.4% when down-regulated by siRNA |
706023 |
| 2.4.2.10 | down |
non-cancerous components do not express OPRT |
706021 |
| 2.4.2.10 | up |
enzyme expression is extremely high in malignant pleural mesothelioma tumor tissue |
760110 |
| 2.4.2.10 | up |
lexpression of OPRT in mucosal carcinoma components, in infiltrative components, in lymphovascularly invasive lesions and in metastatic lymph nodes. No significant correlation between OPRT expression and cancer stage, T-grade or N-grade, but OPRT expression correlates positively with the presence of lymphovascular invasion. OPRT is diffusely expressed to a greater extent, especially in the tumor cells adjacent to the infiltrative margin |
706021 |
| 2.4.2.10 | up |
strong expression of OPRT in prostate cancer cells, significant correlation between OPRT mRNA expression levels and the tumor pathological grade. The OPRT/dihydropyrimidine dehydrogenase expression ratio in the HRPC group is significantly higher than that in the low grade HSPC group |
706025 |
