EC Number   |
Expression |
Reference |
|---|
   2.3.1.B43 | down |
decreased expression of SIRT5 is found in cultured macrophages upon primary or second LPS stimulation |
757084 |
| 2.3.1.B43 | down |
overexpression of AMP-activated protein kinase (AMPK) in mouse hepatocytes downregulates expression of SIRT5 mRNA by 58%. The antidiabetes drug metformin (1 mM), an established AMPK activator, reduces the mouse SIRT5 protein level by 44% in cultured hepatocytes and by 31% in liver in vivo (300 mg/kg, 7 d) |
729700 |
| 2.3.1.B43 | down |
overexpression or metformin-mediated activation of AMPK inhibited SIRT5 expression |
756522 |
| 2.3.1.B43 | down |
SIRT5 is significantly down-regulated in cardiomyocytes upon oxidative stress |
729556 |
| 2.3.1.B43 | down |
women with reduced ovarian reserve or advanced maternal age have decreased SIRT5 mRNA, protein and desuccinylation activity in granulosa and cumulus cells |
730922 |
| 2.3.1.B43 | more |
SIRT5 expression is reported to be regulated by two major cellular regulators of metabolism, peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha), and AMP-activated protein kinase (AMPK) |
756522 |
| 2.3.1.B43 | more |
SIRT5 expression is reported to be regulated by two major cellular regulators of metabolism, peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha), and AMP-activated protein kinase (AMPK). PGC-1alpha overexpression or food withdrawal increases SIRT5 mRNA and protein levels in mouse primary hepatocytes, whereas overexpression or metformin-mediated activation of AMPK inhibits SIRT5 expression |
756522 |
| 2.3.1.B43 | more |
the enzyme expression is not affected by chemical oxidant treatment |
738110 |
| 2.3.1.B43 | up |
cigarette smoke extract induces the enzyme |
738009 |
| 2.3.1.B43 | up |
enhanced expression of SIRT5 in the cerebral tissue of calorie restriction rats compared with rats that remained fed ad libitum |
730103 |
