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Results 1 - 10 of 11 > >>
EC Number Expression Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63down a loss of MGMT expression is noted in 20 cases of 60 total soft tissue sarcomas 703974
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63down extensive methylation of MGMT promoter is associated with loss/reduced protein expression, methylation of MGMT promoter region is essential for methylation-induced silencing of this gene 704064
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63down interleukin-24 down-regulates O6-methylguanine-DNA methyltransferase in melanoma cells, accumulation of functional p53 is essential for interleukin-24-induced down-regulation of O6-methylguanine-DNA methyltransferase 705661
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63down microRNA-603 directly interacts with the 3'-UTR region of enzyme gene and produces a 6fold decrease of both enzyme mRNA and protein upon transfection in glioblastoma cell line in vitro. Downregulation of enzyme expression by microRNA-181d and microRNA-767-3p is due to degradation of the enzyme mRNA. microRNA-221 and microRNA-222 also downregulate the enzyme expression 757010
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63down neither short-term (24 h) nor long-term changes (7 weeks) in S-adenosyl-L-methionine/S-adenosylhomocysteine ratio alter global or MGMT promoter methylation, however, experimentally elevated S-adenosylhomocysteine levels significantly decrease MGMT mRNA levels by more than 50% 702153
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63down there is a good correlation between the increasing MGMT promoter methylation and decreased MGMT expression, in most patients who has been treated with temozolomide, there is decreased MGMT expression in the post treatment sample when compared to the primary sample 705274
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63down treatment with 0.05 mM disulfiram reduces enzyme protein expression 757679
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63more promoter methylation of O6-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53 703393
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63up ependymomas lack MGMT promoter hypermethylation and show high MGMT protein expression 704813
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63up MGMT activity is significantly higher in the group with the lowest consumption of vegetables than in the group with the greatest vegetable consumption 703079
Results 1 - 10 of 11 > >>