EC Number   |
Expression |
Reference |
|---|
   1.21.99.3 | down |
decrease postnatally, persisted into adulthood at low levels |
697631 |
| 1.21.99.3 | more |
no influence of peroxiredoxin 3 on expression oftype 3 iodothyronine deiodinase |
697638 |
| 1.21.99.3 | up |
expression and activity of type 3 iodothyronine deiodinase are elevated in infantile hepatic hemangioma |
697757 |
| 1.21.99.3 | up |
glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in Min6 cells in a dose-dependent manner through a GLP-1 receptor-cAMP-PKA-medicated mechanism, and this effect is inhibited by the protein kinase A inhibitor H-89. Exendin-4, a GLP-1 receptor agonist, and forskolin also stimulates type 3 deiodinase expression in MIN6 cells. A cAMP pathway mediates the pretranslational regulation of D3 expression in MIN6 cells |
734596 |
| 1.21.99.3 | up |
high expressio levels in embryos |
697631 |
| 1.21.99.3 | up |
increase of type 3 deiodinase levels in spinal cord inflammatory lesions, induction of type 3 deiodinase levels in proinflammatory or immunomodulatory monocytes |
701299 |
| 1.21.99.3 | up |
incubation (for 8 h at 37°C) of confluent primary cultures of astroglial cells with 0.1 mM ATP causes a 7fold induction of type 3 iodothyronine deiodinase activity. The activity of type 3 iodothyronine deiodinase significantly raises by the influence of 0.001 mM all-trans retinoic acid during preincubation for 2-3 days |
716049 |
| 1.21.99.3 | up |
short days decrease blood leukocyte dio3 mRNA expression |
744614 |
| 1.21.99.3 | up |
the enzyme activity is increased in kidney, muscle, and liver up to 4fold during fasting |
733734 |
| 1.21.99.3 | up |
the mRNA expression and activity of the zebrafish deiodinase-3 gene is increased locally 1 and 3 days after partial fin amputation |
715101 |
