EC Number   |
Expression |
Reference |
|---|
    1.14.19.17 | down |
gamma-tocotrienol causes downregulation of Des1 expression but is not inhibitory for the enzyme activity |
744418 |
| 1.14.19.17 | down |
natural forms of vitamin E can induce dihydroceramide levels by repressing DEGS1 activity. Adiponectin represses the expression of degs1 in MCF-7 cells |
744398 |
| 1.14.19.17 | up |
Des1 is upregulated under hypoxia |
744686 |
| 1.14.19.17 | up |
Des1 is upregulated under hypoxia. Upregulation of Des1 occurs by saturated fatty acids and anoxia |
744686 |
| 1.14.19.17 | up |
Des2 is upregulated under hypoxia |
744686 |
| 1.14.19.17 | up |
interferon gamma upregulates expression levels of DEGS1 in the human mononuclear cell line THP-1, similarly, interleukin 2 increases expression levels of DEGS1 in human natural killer cells. all trans-Retinoic acid increases the enzyme expression |
744398 |
| 1.14.19.17 | up |
palmitate induces the expression of DEGS1 leading to an associated increase in ceramide levels. Increased levels of palmitate may enhance the synthesis of ceramides by increasing the flux of palmitate substrate and expression rates of DEGS1. Monounsaturated fatty acids, including oleate, are able to attenuate the induction elicited by palmitate and prevent ceramide production |
744398 |
