EC Number   |
Expression |
Reference |
|---|
    1.14.16.4 | down |
enzyme expression is inhibited by a Jak2 inhibitor and partially inhibited by MEK1/2 inhibitor U0126 or PI3K inhibitor LY-294002 |
745572 |
| 1.14.16.4 | down |
enzyme expression is reduced in ganglionic bowel in those affected by pre-operative Hirschsprung's-associated enterocolitis compared to those without Hirschsprung's-associated enterocolitis and healthy controls |
746550 |
| 1.14.16.4 | down |
TPH-1 mRNA levels are significantly decreased in the hypothalami of croaker exposed for 2 weeks to hypoxic conditions compared with those in fish exposed to normoxic conditions. Hypoxia causes a marked decline in hypothalamic TPH protein levels, which is associated with a 65% decrease in hypothalamic TPH enzyme activity and a 60% decrease in 5-hydroxytryptophan levels |
705929 |
| 1.14.16.4 | down |
TPH-2 mRNA levels are significantly decreased in the hypothalami of croaker exposed for 2 weeks to hypoxic conditions compared with those in fish exposed to normoxic conditions. Hypoxia causes a marked decline in hypothalamic TPH protein levels, which is associated with a 65% decrease in hypothalamic TPH enzyme activity and a 60% decrease in 5-hydroxytryptophan levels |
705929 |
| 1.14.16.4 | up |
enzyme expression is induced by prolactin |
745572 |
| 1.14.16.4 | up |
imipramine increases dorsal raphe TPH2 gene expression in a glucocorticoid-dependent manner, increases are due to relief of inhibitory glucocorticoid signaling |
702962 |
| 1.14.16.4 | up |
TPH-1 mRNA is highly expressed in the total RNA extracted from the preoptic anterior hypothalamus and midbrain tegmentum compared with other brain areas |
705929 |
| 1.14.16.4 | up |
TPH-2 mRNA shows high expression in the preoptic anterior hypothalamus, midbrain tegmentum and cerebellum with optic tectum, compared with other brain areas |
705929 |
