EC Number   |
Expression |
Reference |
|---|
    1.14.15.18 | down |
kidney: 25-hydroxycholecalciferol induces a significant downregulation 3 days after injection |
699219 |
| 1.14.15.18 | down |
statistically significantly lower protein expression in malignant ovarian tissue |
695623 |
| 1.14.15.18 | up |
calcitonin induces 25-hydroxyvitamin D3 1alpha-hydroxylase protein levels in AOK-B50 cells transfected with a mouse 25-hydroxyvitamin D3 1alpha-hydroxylase promoter construct (transcription factor C/EBPbeta is involved) |
698881 |
| 1.14.15.18 | up |
expression of 1alpha-hydroxylase is induced via toll-like receptor, TLR, recognition of pathogens in macrophages, but not in colonic cells, i.e. Caco-2 and BBe colonic cell lines. Colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D. |
712885 |
| 1.14.15.18 | up |
genes CYP2R1 encoding vitamin D 25-hydroxylase, CYP27B1 encoding 25-hydroxyvitamin D-1 alpha hydroxylase and CYP24A1 encoding 1,25-dihydroxyvitamin D(3) 24-hydroxylase are upregulated in clear cell renal cell carcinomas compared with normal tissue. CYP24A1 displays a significantly higher expression in tumors than CYP27B1 and CYP2R1, whereas no differences in the expression of these genes are found in healthy renal tissue |
724907 |
| 1.14.15.18 | up |
hyperplastic parathyroid glands from patients with chronic kidney failure normally display a heterogeneous cellularity. 25-hydroxyvitamin D3 1alpha-hydroxylase is expressed at much higher levels in oxyphil cells than in chief cells in these patients. The calcimimetic cinacalcet increases the expression of the enzyme in human parathyroid cultures |
725826 |
| 1.14.15.18 | up |
in Klotho knockout mice |
699920 |
| 1.14.15.18 | up |
kidney: calcitriol and 25-hydroxycholecalciferol induce a significant upregulation 6 days after injection |
699219 |
| 1.14.15.18 | up |
kidney: parathyroid hormone-related protein induces significant upregulation 6 h after injection |
699219 |
