EC Number   |
Expression |
Reference |
|---|
   1.14.15.16 | down |
the enzymatic activity of intestinal 24-hydroxylase is significantly lower in renal failure rats compared to control sham operated rats |
716071 |
| 1.14.15.16 | up |
CYP24A1 is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-dihydroxyvitamin D3 |
716973 |
| 1.14.15.16 | up |
enzyme expression is upregulated in cancer cells |
728214 |
| 1.14.15.16 | up |
intraperitoneal injection of 1,25-dihydroxyvitamin D3 induces dose- and time-dependent increases in both 24-OHase mRNA abundance and enzyme activity in mouse kidney reaching a maximum between 4-8 h, after which it decreases and then maintains a steady value between 18-72 h. Similarly, 1,25-dihydroxyvitamin D3-induced increases in both 24-OHase mRNA and activity are apparent in the duodenum. Although 1,25-dihydroxyvitamin D3 markedly the amount of 24-OHase mRNA in skin between 4 and 6 h, enzyme activity is not detected in this tissue. Pretreatment of mice with cycloheximide (0.4mg/g) potentiates the increase in 24-OHase mRNA abundance but blocks the increase in 24-OHase activity, induced by 1,25-dihydroxyvitamin D3 in kidney and duodenum |
714836 |
| 1.14.15.16 | up |
methyltransferase inhibitor 5-aza-2'-deoxycytidine treatment results in an over 50fold induction of CYP24A1 mRNA expression in Coga1A and HT-29 cells. In colon cancer cells, CYP24A1 gene expression is inducible by methyltransferase and some histone deacetylase inhibitors in a cell line-dependent manner |
728215 |
| 1.14.15.16 | up |
replacement of calcitriol (3 ng per day) significantly increases 24-hydroxylase activity by 17% in rats with renal failure, although the activity remains 15% lower than the controls |
716071 |
| 1.14.15.16 | up |
the enzyme is upregulated in tumor cells compared with normal tissue |
724907 |
| 1.14.15.16 | up |
the vitamin D receptor bound to 1alpha,25(OH)2D3 induces expression of mitochondrial cytochrome P450 24A1 |
736545 |
