EC Number   |
Expression |
Reference |
|---|
    1.14.14.32 | down |
CYP17 mRNA levels are reduced by 50% in CYP17 chimeric compared to wild-type mouse brain, whereas the levels of brain dehydroepiandrosterone levels are comparable |
-, 705402 |
| 1.14.14.32 | down |
in the brain, during the atretic follicles stage, the gene expression drops sharply to the lowest level |
703775 |
| 1.14.14.32 | down |
shRNA treatment significantly decreases CYP17 mRNA and protein levels in vitro. Silence efficiency of three constructed lentivirus shRNAs is 65.5%, 73.7% and 77.4%, respectively. Three constructed lentivirus shRNAs also have silencing effects on CYP17 protein expression, and their silence efficiencies are 50%, 50% and 61%, respectively. In vivo, shRNA still has a specific silencing effect on CYP17 |
706689 |
| 1.14.14.32 | up |
CYP17A1 gene expression continuously rises throughout the ovarian development, except for a slight drop during the primary yolk stage. During the atretic follicles stage, the expression of CYP17A1 is remarkably upregulated and reaches the highest level. During the tertiary yolk stage, brain CYP17AI expression is 3.1fold higher than the primary yolk stage, and 4.4fold higher than that at atretic follicles stage |
703775 |
