EC Number   |
Expression |
Reference |
|---|
   1.14.14.25 | up |
ablation of the sensorimotor cortex induces an increase of Cyp46 immunoreactivity in the ipsilateral cortex in the brain |
-, 712120 |
| 1.14.14.25 | up |
age-associated increase in TrkB activity correlates with a mild yet progressive loss of cholesterol, which, in turn, correlates with increased expression of the cholesterol catabolic enzyme cholesterol 24-hydroxylase. Increased expression of cholesterol-24-hydroxylase in the hippocampus of aged mice |
705612 |
| 1.14.14.25 | up |
Cyp46 is upregulated in traumatic brain injury, specifically in microglia |
711641 |
| 1.14.14.25 | up |
CYP46A1 expression is increased in the retina of voriconazole-treated rats |
-, 735602 |
| 1.14.14.25 | up |
expression of the gene in the mouse embryo as early as day 11.5 and gradual increase in mRNA and protein in postnatal brain. Over a 14-day culture period, during which the neurons extend processes and form increasing numbers of synapses but do not divide, there is a gradual increase in cholesterol 24-hydroxylase mRNA and protein |
701715 |
| 1.14.14.25 | up |
gradual increase in mRNA and protein in postnatal brain |
701715 |
| 1.14.14.25 | up |
intraperitoneal injection of a high dose of valproate (700 mg/kg) results in a modest induction of the mRNA expression of CYP46A1 in the liver, and CYP46A1 in the brain. Intraperitoneal injection of trichostatin A to male mice results in dose dependent increases in the expression of brain and liver CYP46A1 |
-, 702028 |
| 1.14.14.25 | up |
marked time-dependent derepression of the expression of CYP46A1, in response to treatment with the potent histone deacetylase inhibitor trichostatin A. Treatment with 0.0005 mM trichostatin A for 48 h shows highly significant 150fold increase in CYP46A1 expression |
702028 |
