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Results 1 - 7 of 7
EC Number
Expression
Commentary
Reference
down
expression in mast cells is not apparent in healthy subjects
down
hepatic mRNA expression of LTC4S is decreased in presence of NO donor O2-vinyl-1-(pyrrolidin-1-yl)-diazen-1-ium-1,2-diolate, i.e. V-PYRRO/NO. Downregulation may occur via inhibiting NF-kappaB activation independent of IkappaBalpha during hepatic ischemia/reperfusion injury
down
no upregulation by interleukin-4 in the THP-1 cell line
more
is not suppressed by pretreatment with the p38 inhibitor
up
LTC4s increases following spared nerve injury, significant increase 3 days after nerve injury and continues at least for 14 days. LTC4s mRNA is expressed constitutively throughout the grey matter and increases after nerve injury in dorsal horn. This increase in LTC4s mRNA mainly occurrs in cells with small nuclei
up
mRNA levels for the three key enzymes/proteins in the biosynthesis of cysteinyl-leukotrienes, 5-lipoxygenase, 5-LO-activating protein, and LTC4 synthase, are significantly increased in the wall of human abdominal aortic aneurysm
up
significantly elevated immunoexpression of LTC4 synthase observed in perennial allergic rhinitis biopsies
Results 1 - 7 of 7