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DDAH isoforms are expressed in a dynamic,overlapping pattern during embryonic development
alpha-lipoic acid increases the gene expression and activity of DDAH, and signal transducer and activator of transcription STAT3 phosphorylation. Transfection of STAT3 increases DDAH II promoter activity, and alpha-lipoic acid amplifies it. alpha-Lipoic acid-induced increase in DDAH II promoter activity is attenuated in the promoter that has a mutation in the putative STAT3-binding site
DDAH-2 protein expression is higher in osteoarthritic cartilage than in normal cartilage; in chondrocyte mitochondria extracts, DDAH-2 expression is significantly increased after exposure to IL-1beta
following myocardial infarction, left ventricular DDAH activity is increased to 210% of control
treatment of mice with farnesoid X receptor agonist 3-(2,6-dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole, i.e. GW4064, leads to increased expression of DDAH-1 and cationic amino acid transporter CAT-1 in both liver and kidney
Results 1 - 5 of 5