EC Number   |
Expression |
Reference |
|---|
   3.4.22.64 | more |
induction of procaspase-11 expression is delayed in Myd88-/- macrophages infected with DELTAFlag Salmonella typhimurium, although procaspase-11 processing itself remains intact |
731744 |
| 3.4.22.64 | more |
Lipopolysaccharide treatment or type I IFN treatment alone does not cause caspase-11-dependent cell death |
731611 |
| 3.4.22.64 | more |
poly(ADP-ribose) polymerase-1, PARP-1, regulates the expression of caspase-11 following lipopolysaccharide stimulation. PARP-1 is recruited to the caspase-11 promoter region containing predicted nuclear factor (NF)-kappaB-binding sites, but PARP-1 enzymatic activity is not required for the caspase-11 upregulation. PARP-1 can regulate the induction of caspase-11 at a transcriptional level. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB |
717195 |
| 3.4.22.64 | up |
bacterial lipopolysaccharide stimulation of caspase-11 expression in several mouse tissues, particularly in the spleen |
731613 |
| 3.4.22.64 | up |
CASP11 is induced by infection or other pathologic stress. Upregulation of CASP11 in cell lysates of infected wild-type as well as casp1-/- macrophages |
770782 |
| 3.4.22.64 | up |
caspase-11 expression is increased following Helicobacter pylori strain NCTC11638 infection in macrophages. Prostaglandins (PGs) inhibit caspase-11 upregulation, IL-1beta production, and pyroptosis in mice |
771849 |
| 3.4.22.64 | up |
caspase-11 expression is stimulated by TLR signaling, IL-1 signaling, mitochondrial DNA damage, the complement pathway, and IFN signaling involving receptors TLR2, TLR3, TLR4, TLR5, ILR9, IL-1R, mtDNA, C3aR, IFNAR, and IFNGR: The responsible stimulators of the receptors are Pam3CSK4, dsRNA, LPS, flagellin, CpG-rich DNA, interleukin-1beta, c-Gas-STING, C3a, and IFNalpha/beta. Involved pathways and regulation mechanisms, detailed overview |
772221 |
| 3.4.22.64 | up |
caspase-11 is upregulated of by either cisplatin or ischemia-reperfusion |
773812 |
| 3.4.22.64 | up |
cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme |
-, 732915 |
| 3.4.22.64 | up |
increase in pyroptosis-related protein expression is induced by LPS |
-, 773810 |
