EC Number   |
Expression |
Reference |
|---|
   3.4.21.46 | up |
after challenged with Aeromonas hydrophila, the enzyme, at both mRNA and protein levels, is upregulated in the kidney, spleen, liver and head-kidney |
753616 |
| 3.4.21.46 | down |
deguelin, a rotenoid of the flavonoid family, significantly down-regulates the expression of VEGF-D both at the mRNA and protein level in VEGF-D transfected LL/2 Lewis lung cells |
708769 |
| 3.4.21.46 | up |
enzyme expression is increased during adipocyte differentiation |
755129 |
| 3.4.21.46 | up |
enzyme gene and protein expression are increased in the dermal layer of skin specimens from aged subjects (more than70 years old), compared to young subjects (younger than 20 years old) |
752876 |
| 3.4.21.46 | up |
expression of PoDAK increases in kidney, liver, spleen upon infection with viral hemorrhagic septicemia virus or bacterial infection with Streptococcus iniae |
708533 |
| 3.4.21.46 | up |
in lung cancer cell lines, interleukin-7/interleukin-7 receptor increase the expression of VEGF-D and phosphorylation of c-Fos/c-Jun, induce c-Fos and c-Jun heterodimer formation, and enhance c-Fos/c-Jun DNA binding activity to regulate VEGF-D expression |
708370 |
| 3.4.21.46 | up |
overexpression of PDGF-D in PDGF-D low expressing breast cancer cell lines MDA-MB-468 and MCF-7 cells by cDNA transfection shows increased cell proliferation. PDGF-D overexpression is positively correlated with the expression of Notch-1 and Jagged-1, and the expression of mesenchymal markers (Vimentin and ZEB-2) with concomitant decreased expression of epithelial marker E-cadherin. PDGF-D over-expression leads to increased DNA binding activity of NF-kappaB |
707940 |
| 3.4.21.46 | down |
silencing the expression of PDGF-D by siRNA in PDGF-D high expressing MDA-MB-231 and SUM-149 cells shows decreased cell proliferation and increased apoptosis |
707940 |
| 3.4.21.46 | up |
the enzyme is immunologically upregulated by lipopolysaccharide (12 h post injection), Streptococcus iniae (12 h post infection), rock bream iridovirus (6-12 h post infection), and poly I:C (6 h post injection) in spleen tissue |
753602 |
