EC Number   |
Expression |
Reference  |
|---|
   3.4.17.23 | up |
the enzyme expression is upregulated in case of induced liver fibrosis and is further upregulated by additional administration of ACE I inhibitor peptide, pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, in hepatic stellate cells |
708195 |
| 3.4.17.23 | down |
central angiotensin II type 1 receptors reduce ACE2 expression/activity in hypertensive mice |
708683 |
| 3.4.17.23 | down |
angiotensin II downregulates ACE2, but increases the expression of vascular endothelial growth factor and type receptor AT1-R, overview |
710171 |
| 3.4.17.23 | up |
angiotensin peptides modulate the expression of angiotensin converting enzyme II in the cardiovascular system, angiotensin II upregulates ACE2, modulated through activation of Ang II type 1 receptor, AT1R, and increases Ang-(1-7) formation from Ang II, and ACE2 expression is further enhanced by Ang-(1-7) in a positive feedback loop, molecular mechanism, overview. The upregulation is inhibited by Ang-(1-7) Mas receptor blockade through PD98059 |
710214 |
| 3.4.17.23 | up |
high sucrose intake induces ACE2 expression in epididymal adipose tissue and kidney, leading to increased ACE2 and angiotensin-(1-7) levels in the adipose tissue |
710532 |
| 3.4.17.23 | up |
elevated expression in kidney and heart in a rat model with chronic heart failure |
731092 |
| 3.4.17.23 | down |
miR-421 (miRNA) downregulates the expression of ACE2 in human cells by interacting with a specific sequence in its 3'-UTR and thereby repressing translation |
731675 |
| 3.4.17.23 | down |
infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung |
732569 |
| 3.4.17.23 | up |
infection with highly pathogenic avian influenza A H5N1 virus results in increased expression of angiotensin-converting enzyme 2 (ACE2) in serum |
732569 |
| 3.4.17.23 | up |
up-regulated expression in patients with heart failure and hypertension |
732780 |
