EC Number   |
Expression |
Reference |
|---|
    2.3.3.8 | down |
48 h after exhaustion of nitrogen in the culture, the enzyme shows marked decrease (84%) in activity. The enzyme activity decreases in a time period of 20-100 h during lipid accumulation |
-, 718581 |
| 2.3.3.8 | up |
enzyme activity increases with dissolved oxygen and upon ammonium depletion in an ammonium-limited culture |
-, 701861 |
| 2.3.3.8 | up |
enzyme mRNA and protein levels markedly (about 2.5fold) and quickly increase in activated macrophages. Tumour necrosis factor alpha and interferon gamma upregulate enzyme gene expression |
735597 |
| 2.3.3.8 | up |
high glucose upregulates ATP-citrate lyase expression |
755769 |
| 2.3.3.8 | up |
highly induced in ob/ob BTBR mice |
756693 |
| 2.3.3.8 | up |
highly induced in the kidney of overweight or obese patients with chronic kidney disease. Induction is associated with increased ectopic lipid accumulation, glomerulosclerosis, and albuminuria. Acetyl-CoA is the substrate for de novo lipogenesis as well as for histone acetylation. By raising acetyl-CoA concentration ATP-citrate lyase promotes H3K9/14 and H3K27 hyperacetylation leading to up-regulation of several rate-limiting lipogenic enzymes and fibrogenic factors. On the other hand, the excess acetyl-CoA generated as a result of ATP-citrate lyase induction provides the substrate for these lipogenic enzymes to drive de novo lipogenesis leading to ectopic lipid accumulation, a detrimental event toward renal injury |
756693 |
| 2.3.3.8 | up |
in mesangial cells, the enzyme is synergistically induced by high glucose, palmitate, and TNF-alpha via NF-kapaB and PKA pathways |
756693 |
| 2.3.3.8 | up |
low molecular weight cyclin E upregulates enzymatic activity, subsequently increasing lipid droplet formation, thereby providing cells with essential building blocks to support growth |
756335 |
| 2.3.3.8 | down |
mRNA transcript levels decrease during normal macrophage differentiation from bone marrow precursors |
756281 |
| 2.3.3.8 | up |
overexpressed in many cancers. ACLY transcription is promoted by SREBP1 |
756333 |
