EC Number |
BRENDA No. |
Title |
Journal |
Volume |
Pages |
Year |
Organism |
PubMed ID |
---|
2.1.2.3 | 756109 |
Analysis of substrate binding in individual active sites of bifunctional human ATIC |
Biochim. Biophys. Acta |
1866 |
254-263 |
2018 |
Homo sapiens |
29042184 |
2.1.2.3 | 756701 |
Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis |
FEBS J. |
284 |
4233-4261 |
2017 |
Staphylococcus lugdunensis |
29063699 |
2.1.2.3 | 756196 |
Colocalization and sequential enzyme activity in aqueous biphasic systems experiments and modeling |
Biophys. J. |
109 |
2182-2194 |
2015 |
Homo sapiens |
26588576 |
2.1.2.3 | 756643 |
Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents |
Eur. J. Med. Chem. |
115 |
245-256 |
2016 |
Homo sapiens |
27017552 |
2.1.2.3 | 757394 |
Discovery of N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a potent and selective nonclassical antifolate aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) inhibitor |
J. Med. Chem. |
60 |
9599-9616 |
2017 |
Homo sapiens |
29072452 |
2.1.2.3 | 757213 |
High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans |
J. Biol. Chem. |
293 |
4845-4859 |
2018 |
Caenorhabditis elegans |
29414769 |
2.1.2.3 | 756648 |
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase |
Eur. J. Med. Chem. |
139 |
531-541 |
2017 |
Homo sapiens |
28830032 |
2.1.2.3 | 757662 |
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network |
Mol. Cell. Proteomics |
14 |
1079-1092 |
2015 |
Rattus norvegicus |
25687571 |
2.1.2.3 | 757625 |
Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) tranformylase/IMP cyclohydrolase (PurH) in Escherichia coli |
Microbiology |
164 |
982-991 |
2018 |
Escherichia coli |
29799386 |
2.1.2.3 | 757625 |
Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) tranformylase/IMP cyclohydrolase (PurH) in Escherichia coli |
Microbiology |
164 |
982-991 |
2018 |
Escherichia coli K12 |
29799386 |