Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search Reaction

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 9 of 9
EC Number Reaction Commentary Reference
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis - -
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis 2-step mechanism, elucidation of structure-activity relationship, the N-terminal catalytic domain contains the six-stranded antiparallel beta-sheet and the three motifs characteristics of class II aaRS, a HisRS-specific helical domain inserted between motifs 2 and 3 that may contact the acceptor stem of the tRNA, a C-terminal alpha/beta domain may be involved in the recognition of the anticodon stem and loop of tRNAHis 650438
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis interaction mechanism of RNA substrate and enzyme, active site structure 650256
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis mechanism, active site structure, ligand induced structural changes, highly cooperative dynamics 649862
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis N73 is a discriminator base involved in histidylation activity, substrate recognition mechanism 653611
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis relation between the conservation of active site residues and the molecular mechanism of aminoacylation reaction, relevant reaction coordinate and the orientation of the catalytic residue, Arg259, model of active site with the substrates, Mg2+ ions and water, overview. Calculation of the transition state structures of the activation step of aminoacylation reaction using the combined ab-initio/semi-empirical calculation 714477
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis substrate-assisted concerted mechanism, rate of aminoacyl transfer is independent of the interaction between the carboxamide group of Q127 and the alpha-carboxylate carbon 661192
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis the major groove amine of C73 and the 6-keto oxygen of G-1 of tRNAHis participate in hydrogen bonding with histidine-tRNA ligase, while the 5'-monophosphate provides necessary electrostatic interactions with the positive residues of enzyme active site 661936
Show all pathways known for 6.1.1.21Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.21ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis two molecules of ATP and histidine are bound per molecule of enzyme 369
Results 1 - 9 of 9