EC Number   |
Reaction |
Reference |
|---|
    5.4.99.2 | (R)-methylmalonyl-CoA = succinyl-CoA |
evidence for radical intermediates |
3517 |
| 5.4.99.2 | (R)-methylmalonyl-CoA = succinyl-CoA |
intrinsic hydrogen isotope effect is 51 due to multidimensional tunneling. Corner-cutting tunneling decreases the distance over which the system tunnels without a comparable increase in either the effective potential barrier or the effective mass for tunneling |
682544 |
| 5.4.99.2 | (R)-methylmalonyl-CoA = succinyl-CoA |
mechanism |
3502, 3516, 3519 |
| 5.4.99.2 | (R)-methylmalonyl-CoA = succinyl-CoA |
mechanism, overview, a gradual weakening of the electrostatic energy between the protein and the ribose leads to a progressive increase in the activation energy barrier for Co-C bond homolysis, key role for the conserved polar glutamate residue in controlling the initial generation of radical species |
727036 |
| 5.4.99.2 | (R)-methylmalonyl-CoA = succinyl-CoA |
ONIOM calculations based on protein structure. Homolytic Co-C5 bond cleavage in the 5-deoxyadenosylcobalamin cofactor is a stepwise process in which conformational changens in the 5-deoxyadenosine moiety proceed the actual homolysis step. The movement of the deoxyadenosine moity during homolysis positions the resulting 5-deoxyadenosyl radical for the subsequent hydrogen atom transfer from the substrate |
680348 |
