EC Number   |
Reaction |
Reference |
|---|
    5.1.3.2 | UDP-alpha-D-glucose = UDP-alpha-D-galactose |
- |
- |
| 5.1.3.2 | UDP-alpha-D-glucose = UDP-alpha-D-galactose |
a nucleoside diphospho-4-ulose of the configuration D-xylo-4-hexosulose is an intermediate in the reaction |
2324 |
| 5.1.3.2 | UDP-alpha-D-glucose = UDP-alpha-D-galactose |
presence of at least one essential Arg at the substrate-binding region of the active site |
- |
| 5.1.3.2 | UDP-alpha-D-glucose = UDP-alpha-D-galactose |
reaction mechanism, overview |
-, 747460 |
| 5.1.3.2 | UDP-alpha-D-glucose = UDP-alpha-D-galactose |
revolving door reaction mechanism, Tyr149 is the base catalyst for hydride transfer, overview. The enzyme undergoes a conformational change upon binding of the UDP sugar, which is in fact a result of the binding of the UMP-moiety of the substrate. The conserved lysine from the YxxxK motif plays an important role in the activation of the cofactor, as due to the conformational change, the 6-ammonium group is hydrogen-bonded to both the 2'- and 3'-hydroxylgroups of the nicotinamide riboside of NAD+ |
747460 |
| 5.1.3.2 | UDP-alpha-D-glucose = UDP-alpha-D-galactose |
Ser124 and Tyr149 are likely to play important roles in the catalytic mechanism |
- |
| 5.1.3.2 | UDP-alpha-D-glucose = UDP-alpha-D-galactose |
structurereactivity studies and reaction mode, acid-base catalysis of hydride transfer, overview |
726547 |
