4.2.3.39 | (2E,6E)-farnesyl diphosphate + H2O = 8-epi-cedrol + diphosphate |
reaction mechanism and cyclization of 8-epi-cedrol. Allylic carbocation formation, isomerization to nerolidyl diphosphate, and cyclization generate the monocyclic bisabolyl cation, a hydride shift is followed by two cyclizations to yield the cedryl cation, and the reaction is terminated by quenching the tricyclic cation with a hydroxide equivalent to form 8-epicedrol, overview |
690608 |