EC Number   |
Reaction |
Reference |
|---|
    4.2.1.1 | H2CO3 = CO2 + H2O |
carbonic anhydrase III is limited in rate by a step occuring outside the actual interconversion of CO2 and HCO3- and involving a change in bonding to hydrogen exchangeable with solvent water |
33533 |
| 4.2.1.1 | H2CO3 = CO2 + H2O |
interconversion of CO2 and water to bicarbonate and a proton. The general catalysis of CA is a metal-hydroxide ping-pong mechanism composed of two independent steps. The first step of catalysis is initiated by nucleophilic attack on the carbon of CO2 by the metal-bound hydroxide to yield bicarbonate, which is subsequently displaced by a water molecule. The second step is the removal of a proton from the now metal-bound water via an ordered water network and a residue acting as a weak base, which is typically a His at the opening of the active site |
-, 746623 |
| 4.2.1.1 | H2CO3 = CO2 + H2O |
mechanism |
33598 |
| 4.2.1.1 | H2CO3 = CO2 + H2O |
reaction mechanism, analysis of the restoring step of the carbonic anhydrase catalytic cycle for natural and promiscuous substrates, natural HCO3-x02and promiscuous H2NCOHN- products, catalytic reaction mechanism, NPT molecular dynamics simulations, overview |
746912 |
| 4.2.1.1 | H2CO3 = CO2 + H2O |
reaction mechanism, model of the active site designed on the basis of the X-ray crystal structure, proposed for both metal ions similar reaction pathways consisting in the nucleophilic attack by the metal bound hydroxide to the carbon dioxide with bicarbonate formation, in a next internal rotation of this last fragment, and then in the formation of a species ready for the product removal, overview |
716443 |
| 4.2.1.1 | H2CO3 = CO2 + H2O |
reaction mechanism, overview |
714191 |
| 4.2.1.1 | H2CO3 = CO2 + H2O |
the catalytic mechanism for the CO2 hydration reaction consists of two steps. In the first step a zinc-bound hydroxide leads the nucleophilic attack on a CO2 molecule with formation of bicarbonate bound to the zinc ion, which is then substituted by a water molecule. The second step, the rate limiting one, consists of the regeneration of the enzyme reactive species, the zinc-bound hydroxide, via a proton transfer reaction, which occurs from the zinc-bound water molecule to the external buffer. This process is generally assisted by an enzyme residue which acts as proton shuttle |
-, 747974 |
| 4.2.1.1 | H2CO3 = CO2 + H2O |
the rate limiting step in catalysis of bicarbonate dehydration by HCA II is an intramolecular proton transfer from His64 to the zinc-bound hydroxide |
713954 |
| 4.2.1.1 | H2CO3 = CO2 + H2O |
zinc-hydroxide mechanism, rate-determining H+ transfer step in catalytic mechanism |
33597 |
