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Results 1 - 3 of 3
EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.8.1.9(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2, see also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining) -
Display the word mapDisplay the reaction diagram Show all sequences 3.8.1.9(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide proposed reaction mechanism, conserved residue Arg134 plays a key role in the dehalogenation process. Residues Arg107, Arg134 and Tyr135 interact with the substrates and are the catalytic residues of DehD that are involved in the dehalogenation of D-2-chloropropionate and D-2-bromopropionate, while Glu20 activates the water molecule that attacks the carbon halogen bond on the alpha-carbon, thereby releasing chloride ion 733999
Display the word mapDisplay the reaction diagram Show all sequences 3.8.1.9(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide the reaction mechanism of dehalogenation is catalysed by hydrolytic SN2-substitution reaction 733552
Results 1 - 3 of 3