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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.7.1.7nonane-4,6-dione + H2O = pentan-2-one + butanoate putative serine hydrolase -, 287796
Display the word mapDisplay the reaction diagram Show all sequences 3.7.1.7nonane-4,6-dione + H2O = pentan-2-one + butanoate reaction mechanism, the reaction catalyzed by OPH is typical of alpha/beta-hydrolases, except that the cleaved bond is between two carbon atoms. Here electron delocalization seems to play an essential role. Upon C-C bond breaking, the negative charge on CO1' is probably stabilized by hydrogen bonds to the backbone NH of Ser66 and Val67, thus forming a second oxyanion hole. This anion-binding beta3-alpha1 loop might promote spontaneous oxidation of Cys172 to a sulfonate -, 733656
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