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EC Number Reaction Commentary Reference
Show all pathways known for 3.6.1.40Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.40guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate - -
Show all pathways known for 3.6.1.40Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.40guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate the hydrolytic base is E119, the dual specificity typical for the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family is due to a common active site for guanosine pentaphosphate and polyphosphate hydrolysis, R22 and R267, residing in different domains, are crucial for guanosine pentaphosphate specificity as they interact with the unique 3'-ribose phosphorylation 688392
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