EC Number |
Reaction |
Reference |
---|
3.4.11.10 | release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids |
active site structure involving His97, Asp117, Asp179, Glu151, Glu152, and His256 |
664709 |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
- |
- |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
active site residue Glu151 is essential for activity acting as a general acid/base during the catalytic reaction, mechanism of peptide hydrolysis |
664065, 665187 |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
active site structure and mechanism |
650077 |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
active site structure, reaction mechanism |
653895 |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
active site structure, reaction mechanism involving divalent metal ions, overview |
664035 |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
active site structure, reaction mechanism involving the two zinc ions |
653895 |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
catalytic mechanism |
652573, 665072 |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
Glu354 is essential for Zn2+-binding and catalytic activity, Arg356 is involved in catalysis acting as a general base that accepts a proton and activates the water nucleophile, other active site residues are Lys270, Glu354, ASp352, Lys282, Asp275, and Asp293, mechanism |
665105 |
3.4.11.10 | Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. |
mechanism. Substrate only binds to the first metal binding site |
81186 |