EC Number   |
Reaction |
Reference |
|---|
    3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
acts on organophosphorous compounds, such as paraoxon, including esters of phosphonic acid and phosphinic acids. Inhibited by chelating agents, requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase |
- |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
catalytic mechanism |
678032, 680347 |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
catalytic mechanism and active site structure, substrate docking mechanism |
663774 |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
catalytic mechanism involving His134 and His115 as well as a Ca2+ ion, active site structure, overview |
666426 |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
catalytic mechanism, the effects of substrate orientation on the mechanism of the enzyme, energetic parameters, overview |
666526 |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
catalytic reaction mechanism involving residue Asp269, and role of Asp270 for the catalytic function, molecular dynamics and modelling, overview. The reaction is supposed to proceed by a two-step addition-elimination (An + Dn) mechanism, which goes through a common pentavalent intermediate observed in phosphoryl transfer reactions. The first step is the activation of H2O by Asp269 and Glu53 to form a nucleophile hydroxide and a metastable pentavalent complex. Both the residues Asn168 and Asn224 help the leaving group leave through hydrogen bonds |
751626, 754801 |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
catalytic reaction with orpanophosphonates starts with cleavageof the P-O bond. Reaction proceeds through a displacement mechanism and generates a chiral product in situ with an inversion of stereochemical configuration at the phosphorous atom |
683351 |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
enzyme-substrate complex structure analysis and reaction mechanism, the my-hydroxo bridge between the metal ions initiates the hydrolytic reaction, roles of alpha- and beta-metal ions, contribution of grouns-state destabilization to catalysis, overview, Michaelis complex, transition state, and product structure, overview |
681465 |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
hypothetic mechanism of C-P bond cleavage in methylphosphonic acid by recombinant His6-tagged OPH, overview |
749684 |
| 3.1.8.1 | an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol |
kinetics and mechanism |
646517 |
