EC Number   |
Reaction |
Reference |
|---|
   3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
- |
- |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
2-step mechanism, pyrimidine dimer-DNA glycosylase and an apurinic/apyrimidinic endonuclease |
170694, 170695, 170697, 170698, 170699, 170700, 170701, 170703, 170706, 170713, 170714 |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
beta-elimination mechanism, imino intermediate |
170714, 170716, 170717 |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
cleavage on the 3'-side of the apyrimidinic site |
170695, 170697 |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
cleavage on the 5'-side of dimers |
170696, 170700, 170701, 170703, 170704, 170706, 170708, 170710, 170713, 170714 |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
damaged DNA substrate recognition mechanism, 2 distinct catalytic activities: cleavage of the glycosyl bond at the 5'side of pyrimidine dimer and subsequent scission of the phosphodiester bond at the 3' position of an abasic site through beta-elimination, the enzyme also scans nontarget sequences to search for lesions in DNA duplexes, glycosylase active site involves the catalytic residues Arg3, Glu23, Arg22, and Arg26 and the amino terminus which forms an imino-covalent intermediate with C1' of the 5' side of the thymidine-dimer |
656844 |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
dsDNA is an effective substrate vor Py-Py correndonucleases I and II, only correndonuclease I can degrade ssDNA |
170711 |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
for DNA repair the combined action of Py-Py correndonuclease I and II is necessary |
170709, 170711 |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
minimum chain length: longer than 10 nucleotides |
170702, 170708, 170711 |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate |
processive |
170700, 170701, 170714, 170717 |
