EC Number   |
Reaction |
Reference |
|---|
   3.1.21.4 | endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates |
- |
- |
| 3.1.21.4 | endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates |
autoinhibition/activation mechanism |
652931 |
| 3.1.21.4 | endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates |
residue H291 is the direct catalytic residue, N308 is important for the structural integrity of the betabetaalpha motif, while D317 and D321 are involved in metal ion binding |
684042 |
| 3.1.21.4 | endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates |
residues D311 and N334 coordinate the cofactor. H312 acts as a general base actiating a water molecule for the nucleophilic attack. K337 together with R340 and D345 are located close to the active center and are essential for correct folding of cataloytic motif, while D345, R264 and D273 may be directly involved in DNA binding |
683779 |
