EC Number |
Reaction |
Reference |
---|
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate |
both subunits would appear to have a role in binding and orienting the leaving group of farnesyl diphosphate approximately for catalysis |
637521 |
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate |
enzyme constitutes the protein prenyltransferase family of enzymes |
636537, 637503, 637507, 637523 |
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate |
farnesyl diphosphate binds exclusively to the beta subunit |
637505 |
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate |
farnesyl diphosphate binds the enzyme in a two step process that may involve an enzyme conformational change, the enzyme-substrate complex then rapidly reacts with the peptide substrate to form a product, and product release is the rate-limiting step in catalysis |
636537, 637499 |
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate |
kinetic mechanism |
636537, 637499, 637502, 637503, 637513, 637514, 637523 |
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate |
leucine makes the protein a substrate for EC 2.5.1.59. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Substrates of prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heteotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. A zinc metalloenzyme that requires Mg2+ for activity |
- |
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate |
The enzyme preferentially farnesylates CaaX sequences ending in methionine, cysteine or serine. Enzyme also attaches geranylgeraniol to some CaaX sequences ending in methionine, leucine and cysteine. Substrate overlap may occur between the Saccharomyces cerevisae farnesyl transferase and geranylgeranyltransferase types I in vivo |
637507 |
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate |
This enzyme, along with geranylgeranyltransferase types I, EC 2.5.1.59 and II, EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine |
- |