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Results 1 - 9 of 9
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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O active site with conserved jelly-roll motif, cysteine residues are not directly involved in the coordination of the metal ion 440320
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O catalytic reaction is under steric regulation 440325
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O Cys106 is involved in substrate binding, Cys255 is involved in maintaining the protein structure 440317
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O isopenicillin-N synthase is the main rate-limiting enzyme for penicillin-G biosynthesis 714549
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O ligation of substrate to the iron centre 440322
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O radical pathway, analogous to the first step of a radicalbased hydroxylation reaction 672246
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O removal of 4 hydrogen atoms to form the 4-membered beta-lactam and the 5-membered thiazolidine ring 440314
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O structure and mechanism 440320, 440322, 440323, 440325
Display the word mapDisplay the reaction diagram Show all sequences 1.21.3.1N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O the hydroperoxide-ferrous intermediate, formed by O2-activated H atom abstraction from the substrate, can exploit different reaction pathways and interactions with the substrate govern the final pathway 714183
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