  1.1.3.39 | adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2 |
A heme-containing flavoprotein, FAD. Other purine and pyrimidine nucleosides, as well as 2'-deoxynucleosides and arabinosides, are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps: 1. adenosine and O2: 5'-dehydroadenosine and H2O2 2. 5'dehydroadenosine and O2: 9-riburonosyladenine + H2O2 with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water |
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