EC Number   |
Reaction |
Reference |
|---|
    1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
a steady-state ordered Bi Bi kinetic mechanism in which IMP binds first followed by NAD+, and product release is ordered. Hydride transfer appears not to be rate-limiting. The pH-rate profile indicates one deprotonated group essential for catalysis |
-, 741400 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
Arg418 is involved in the reaction mechanism as catalytic base |
667644 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
covalent enzyme reaction intermediate, hydrolysis of enzyme-XMP is rate-limiting and requires the adoption of the closed conformation, Arg418 is involved in the reaction mechanism as catalytic base, Thr321 is involved in both hydride transfer and hydrolysis |
667626 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
enzyme acts on the hydroxyl group of the hydrated derivative of the substrate, ordered bi-bi mechanism |
347915, 347928 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
IMP and K+ can bind randomly to the free enzyme, while NAD+ does not react unless K+ or both K+ and IMP are present on the enzyme |
347924 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
IMP binds first, followed by NAD+, NADH dissociates from the ternary complex first, then XMP is released |
347915 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
IMP binds first, XMP is released last |
347931 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
mechanism is partially random |
347924, 347925 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
ordered sequential mechanism |
347931, 347940, 347945 |
| 1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ |
reaction and kinetic mechanism, an Arg residue is involved in catalysis as general base |
668351 |
