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Results 1 - 3 of 3
EC Number Reaction Commentary Reference
Show all pathways known for 4.4.1.20Display the word mapDisplay the reaction diagram Show all sequences 4.4.1.20leukotriene C4 = leukotriene A4 + glutathione - -
Show all pathways known for 4.4.1.20Display the word mapDisplay the reaction diagram Show all sequences 4.4.1.20leukotriene C4 = leukotriene A4 + glutathione random rapid equilibrium mechanism 644489
Show all pathways known for 4.4.1.20Display the word mapDisplay the reaction diagram Show all sequences 4.4.1.20leukotriene C4 = leukotriene A4 + glutathione the thiolate of glutathione acts as a nucleophile attacking C6 of leukotriene A4 forming a S-C6 bond, a proton is transferred from the guanidinium of Arg31 to the epoxide ring oxygen resulting in opening of the epoxide ring and stabilization of the LTC4 product complex. The tail-to-head orientation appears to be the most likely substrate orientation 730555
Results 1 - 3 of 3