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leukotriene C4 = leukotriene A4 + glutathione
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leukotriene C4 = leukotriene A4 + glutathione
random rapid equilibrium mechanism
leukotriene C4 = leukotriene A4 + glutathione
the thiolate of glutathione acts as a nucleophile attacking C6 of leukotriene A4 forming a S-C6 bond, a proton is transferred from the guanidinium of Arg31 to the epoxide ring oxygen resulting in opening of the epoxide ring and stabilization of the LTC4 product complex. The tail-to-head orientation appears to be the most likely substrate orientation
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