EC Number   |
Reaction  |
Reference |
|---|
   3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
Asp375 acts as a critical determinant for the stereoselective introduction of the 12R-hydroxyl group, possibly assisted by Gln134 and thus the biological activity of leukotriene B4 |
647012 |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase |
646981, 646985, 646986, 646991, 646992, 646993, 646999, 647000, 647001, 647002, 647007, 647009, 647010, 647011, 647012, 647015, 647018, 647019, 647021, 647022 |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
enzyme contains two partly overlapping active sites which influence each other |
647018, 647021, 647022 |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity |
647015 |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
mechanism |
646999 |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity |
647011, 647015 |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
pathway |
647018 |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
Ser415 plays a key role in regulating epoxid hydrolase activity |
647021 |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 |
the aminopeptidase activity is dependent upon an unmodified cysteine residue, by modifying this cysteine with a small CH3S group it is possible to separate the two enzymatic activities, the aminopeptidase activity and epoxid hydrolase activity, from each other |
647022 |
