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Results 1 - 8 of 8
EC Number
Reaction
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leukotriene A4 + H2O = leukotriene B4
Asp375 acts as a critical determinant for the stereoselective introduction of the 12R-hydroxyl group, possibly assisted by Gln134 and thus the biological activity of leukotriene B4; bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase
leukotriene A4 + H2O = leukotriene B4
bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase
leukotriene A4 + H2O = leukotriene B4
bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase; enzyme contains two partly overlapping active sites which influence each other; pathway
leukotriene A4 + H2O = leukotriene B4
bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase; enzyme contains two partly overlapping active sites which influence each other; Ser415 plays a key role in regulating epoxid hydrolase activity
leukotriene A4 + H2O = leukotriene B4
bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase; enzyme contains two partly overlapping active sites which influence each other; the aminopeptidase activity is dependent upon an unmodified cysteine residue, by modifying this cysteine with a small CH3S group it is possible to separate the two enzymatic activities, the aminopeptidase activity and epoxid hydrolase activity, from each other
leukotriene A4 + H2O = leukotriene B4
bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase; His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity; mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity
leukotriene A4 + H2O = leukotriene B4
bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase; mechanism
leukotriene A4 + H2O = leukotriene B4
bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase; mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity
Results 1 - 8 of 8