EC Number |
Reaction |
Reference |
---|
2.8.1.6 | dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin |
mechanism |
645587, 645600, 645602, 645612, 691001 |
2.8.1.6 | dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin |
radical chemistry is involved in the mechanism of biotin synthase |
645583 |
2.8.1.6 | dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin |
reaction proceeds via intermediate involving the (2Fe-2S) cluster, with a rate-determining step following the formation of this intermediate |
661113 |
2.8.1.6 | dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin |
substrates are placed between the (4Fe-4S) cluster, essential for radical generation, and the (2Fe-2S) cluster |
645596 |
2.8.1.6 | dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin |
the reaction proceeds in two distinct steps involving mercaptodethiobiotin as an intermediate |
630 |