EC Number   |
Reaction  |
Reference |
|---|
    1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
A flavoprotein (FAD, FMN). Ferricyanide can act as accetor |
- |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
cysteine and serine are active site base residues. One-site ping-pong mechanism with fumarate as electron acceptor |
390913 |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
light |
- |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
light sensitivity seems to result in a conformational change and a partial loss of enzymatic activity |
390911 |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
mechanism, pyrimidine biosynthetic pathways |
390912 |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
ping-pong bi-bi mechanism |
656747 |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
ping-pong mechanism |
390916 |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
sulfhydryl groups suggested to be located near the active site, suggested that enzyme produces superoxide free radicals upon reaction with oxygen |
390909 |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
the active site contains a water filled cavity buried beneath a highly conserved and flexible loop. Orotate is bound by four conserved asparagine side chains. Implications for differences in substrate binding and in the catalytic mechanism between the different enzyme families are given |
390915 |
| 1.3.98.1 | (S)-dihydroorotate + fumarate = orotate + succinate |
two-site ping-pong mechanism, catalytic base is serine |
655517 |
