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Results 1 - 4 of 4
EC Number
Reaction
Commentary
Reference
arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O
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arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O
arsenate reduction by glyceraldehyde-3-phosphate dehydrogenase may take place during or as a consequence of, the arsenolytic cleavage of the thioester bond formed between the enzyme’s C149 and the 3-phosphoglycerol moiety of the substrate
arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O
first reaction step is a nucleophilic displacement reaction by C10 on dianionic arsenate. Second step is a preferential nucleophilic attack of C82 on the monoanionic C10-arsenate intermediate stabilized by S17. Thiolate form of C82 is stabilized by an eight-residue alpha helix flanked by C82 and C89 and a hydrogen bond with T11. during the final step, C89 is activated as a nucleophile by structural alterations of the redox helix
arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O
reaction mechanism
Results 1 - 4 of 4