EC Number   |
Reaction |
Reference |
|---|
    1.14.11.17 | taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2 |
- |
- |
| 1.14.11.17 | taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2 |
mechanism |
658130, 658984 |
| 1.14.11.17 | taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2 |
the key step in the catalytic cycle of the alpha-ketoglutarate-dependent dioxygenases is the hydrogen transfer process. A concerted mechanism takes place, where the H atom transfer happens simultaneously with the electron transfer from taurine to the Fe=O cofactor |
743152 |
| 1.14.11.17 | taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2 |
the TauD mechanism begins with the bidentate coordination of 2-oxoglutarate to Fe(II) displacing two water ligands. Taurine then binds to the active site resulting in the displacement of the apical H2O and formation of a 5-coordinate Fe(II) center. O2 binds to the open coordination site on Fe(II), yielding an Fe(III)-superoxo species. Subsequent oxidative decarboxylation of 2-oxoglutarate leads to formation of a Fe(IV)=O intermediate that triggers hydroxylation of the C1 carbon of taurine via hydrogen atom abstraction and radical rebound chemistry The hydroxylated taurine spontaneously decomposes to sulfite and aminoacetaldehyde |
725787 |
