EC Number   |
Reaction |
Reference |
|---|
   2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
PCAF and Gcn5 protein, fully ordered Bi-Bi kinetic mechanism with acetyl-CoA binding before histone H3 |
487095, 487096, 487097 |
| 2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
ping-pong catalytic mechanism of bi-substrate histone acetyltransferase KAT8 |
736051 |
| 2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
ping-pong mechanism |
487074 |
| 2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
ping-pong mechanism, enzyme form NII |
487069 |
| 2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
rapid equilibrium ordered bireactant mechanism |
487072 |
| 2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
sequential mechanism in which acetyl-CoA and H3 bind to a complex of isoform Rtt109 and histone chaperone Vps75 without obligate order, followed by the direct attack of the unprotonated epsilon-amino group on acetyl-CoA, transferring the acetyl-group to H3 lysine residues The chemical attack of substrate lysine on the bound acetyl-CoA is the rate-limiting step of catalysis |
718878 |
| 2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
ternary complexed mechanism for PCAF and Gnc5 |
487096, 487097 |
