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EC Number
Posttranslational Modification
Commentary
Reference
3.4.22.2
no modification
nonglycosylated enzyme
95685
3.4.22.2
proteolytic modification
the proenzyme is activated by cleavage of the prosegment
667324
3.4.22.2
proteolytic modification
the zymogen of papain contains a pro-peptide at the N-terminus of the catalytic domain. Pro-peptide contains residues which act as pH-sensors in zymogen activation cascade. The conserved Asp72 residue of the pro-peptide, is a highly conserved residue of the GXNXFXD motif that is an important pH sensor in the zymogen activation process and the pro-peptide part can also be a useful target of protein engineering for altering the activation pH of a protease
753357
3.4.22.2
side-chain modification
propapain is a thio-containing but catalytically inactive protein, that is a structural isomer of papain that can be transformed into papain by thiol-disulfide interchange initiated by addition of a suitable nucleophile such as thiolate
95707
3.4.22.2
side-chain modification
propapain is activated by intramolecular thiol-disulfide exchange which is catalyzed by cysteine
95681
3.4.22.2
side-chain modification
the enzyme is produced as an inactive precursor
95685
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