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Results 1 - 6 of 6
EC Number Posttranslational Modification Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.2no modification nonglycosylated enzyme 95685
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.2proteolytic modification the proenzyme is activated by cleavage of the prosegment 667324
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.2proteolytic modification the zymogen of papain contains a pro-peptide at the N-terminus of the catalytic domain. Pro-peptide contains residues which act as pH-sensors in zymogen activation cascade. The conserved Asp72 residue of the pro-peptide, is a highly conserved residue of the GXNXFXD motif that is an important pH sensor in the zymogen activation process and the pro-peptide part can also be a useful target of protein engineering for altering the activation pH of a protease 753357
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.2side-chain modification propapain is a thio-containing but catalytically inactive protein, that is a structural isomer of papain that can be transformed into papain by thiol-disulfide interchange initiated by addition of a suitable nucleophile such as thiolate 95707
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.2side-chain modification propapain is activated by intramolecular thiol-disulfide exchange which is catalyzed by cysteine 95681
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.2side-chain modification the enzyme is produced as an inactive precursor 95685
Results 1 - 6 of 6