EC Number   |
Posttranslational Modification |
Reference |
|---|
   3.4.21.B27 | glycoprotein |
mature proprotein convertase 7 is partially sulfated, Cys699 and Cys704 are palmitoylated at its cytosolic tail. The enzyme also undergoes N-glycosylation |
717835 |
| 3.4.21.B27 | glycoprotein |
zymogen is N-glycosylated |
651865 |
| 3.4.21.B27 | lipoprotein |
the enzyme has palmitoylated cysteines, Cys699 and Cys704 within its C-terminus, these posttranslational modifications are not required for transferrin receptor 1 shedding |
731888 |
| 3.4.21.B27 | proteolytic modification |
after autocleavage, proprotein convertases (PCs) exit the endoplasmatic reticulum. They remain bound to their inhibitory cleaved prosegments in latent form until arrival at the cell surface or, in the case of furin, in acidic endosomes, probably to avoid precocious activation or degradation of their substrates. Activated furin can then recycle from endosomes to the trans-Golgi network by binding to specific adaptors in the cytosol |
753199 |
| 3.4.21.B27 | proteolytic modification |
propeptide is autocatalytically removed during maturation |
649651 |
| 3.4.21.B27 | proteolytic modification |
zymogen is processed to mature enzyme in the endoplasmic reticulum |
651865 |
| 3.4.21.B27 | side-chain modification |
Cys699 and Cys704 are palmitoylated |
717869 |
