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EC Number	Posttranslational Modification	Commentary	Reference
2.7.7.86	more	glutamylation and deglutamylation of cGAS tightly modulate immune responses to infection with DNA viruses. Polyglutamylation of cGAS by the enzyme TTLL6 impeded its DNA-binding ability, whereas TTLL4-mediated monoglutamylation of cGAS blocks its synthase activity. Conversely, carboxypeptidase CCP6 removes the polyglutamylation of cGAS, whereas CCP5 hydrolyzes the monoglutamylation of cGAS, which together lead to the activation of cGAS	739154

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Release 2023.1 (January 2023)